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How ICSI Technology Enhances IVF Egg Fertilization

11255204 - human sperm and egg lifeICSI – Intracytoplasmic Sperm Injection – is a specialized egg fertilization technique used during the IVF process. Look: ICSI bypasses a number of common reproductive conditions preventing sperm from fertilizing an egg. A single sperm cell is injected directly into an egg under the guidance of a microscope. ICSI has revolutionized the treatment of male-factor infertility.

Why is ICSI important?

  • ICSI is used to maximize the rate of egg fertilization
  • ICSI lessens the chances of sperm not being able to penetrate the wall of the egg

ICSI is recommended for most couples undergoing IVF – especially these candidates:

  • Unexplained infertility – known as idiopathic infertility – when the cause cannot be pinpointed
  • Male-factor infertility – a man’s sperm is not able to fertilize a woman’s egg
  • Combined female- and male-factor infertility

Today, ICSI is routinely recommended to improve fertilization in all IVF cases – regardless of diagnosis.

Sperm Retrieval for ICSI

When a man has a low sperm count and/or motility, a semen sample is collected through masturbation. The semen sample is processed in a special solution to obtain optimum ICSI results.

When a man is suffering from azoospermia – no sperm in ejaculate – sperm is microsurgically retrieved from the testicle or epididymis. This is commonly known as testicular sperm retrieval. Microsurgery to remove sperm from the testicles or epididymis can be performed under local or general anesthesia and requires short recovery periods.

Obstructive Azoospermia (no sperm in semen) can be corrected by the surgical removal of sperm directly from the testis or epididymis of the testicle.

  • Microsurgical Epididymal Sperm Aspiration (MESA)
  • Percutaneous Epididymal Sperm Aspiration (PESE)
  • Testicular Sperm Extraction (TESA)

Non-Obstructive Azoospermia (sperm count with impaired sperm) may be caused by hormonal problems, testicular failure, varicocele, or varicose veins in the testicles. Non-Obstructive Azoospermia can be corrected through TESE – testicular sperm extraction. TESE is a surgical technique using fine needle aspiration performed with local anesthesia.Read more: How ICSI Technology Enhances IVF Egg Fertilization

Discover Needle-Free IVF at New Hope Fertility Center

25085067 - portrait of happy mother and babyWe are proud to offer our patients a new, simple and convenient IVF treatment protocol. Look: Needle-Free IVF! This revolutionary IVF protocol eliminates the fear, pain, and anxiety many patients experience with needles. Our Needle-Free IVF protocol stimulates a woman’s ovaries into producing multiple egg follicles through the use of oral fertility medications. The best part? Hormone levels are measured through urine and saliva tests during a Needle-Free IVF cycle.

Needle-Free IVF Benefits

Through Needle-Free IVF, patients are able to administer hormone stimulation in a less-invasive manner.

  • No shots
  • No needles
  • No injections
  • No blood draws

Needle-Free IVF Protocol

Why Needle-Free IVF is patient-friendly.

  • Improves patient safety
  • Improves patient compliance with medication regimen
  • Reduces possibility of error in medication administration
  • Eliminates the risk of accidental needle sticks

Needle-Free IVF Fertility Medications

Depending on the woman’s medical needs, an oral fertility medication – typically Clomid – is prescribed to gently stimulate her ovaries into producing multiple eggs. Synarel is delivered nasally 36 hours prior to surgical egg retrieval.

  • Clomid or Femara to stimulate egg production
  • Synarel to trigger ovulation
  • Oral progesterone tablets
  • Vaginal progesterone suppositories

Read more: Discover Needle-Free IVF at New Hope Fertility Center

How In Vitro Maturation (IVF/M) Helps to Increase IVF Pregnancy Success Rates

timearticle2IVF in conjunction with egg maturation in a laboratory setting (IVF/M) increases a woman’s chances of using at least some of her immature eggs for in vitro fertilization and transfer. Look: Through In Vitro Maturation (IVF/M or IVM) technology, Dr. John Zhang is able to retrieve and bring some of your immature eggs to maturation in vitro. Why does this make a difference? Typically in past conventional IVF procedures, only mature eggs were surgically retrieved to be fertilized in vitro.


A Conventional IVF procedure requires a woman to undergo multiple hormone injections to help produce 10 to 15 egg follicles as they reach maturity while they are still in her ovaries. In addition, the patient must endure multiple, regular ultrasounds and blood tests during a one month fresh IVF cycle.

The IVF/M procedure matures a woman’s eggs in vitro – in the laboratory – after they have been surgically retrieved in an immature stage. Here’s the deal: IVF/M requires fewer fertility medications and only a couple of ultrasound and blood tests during a typical one month cycle.

IVF/M cycle fertility medications are typically available in pill and suppository form. The best part? Because fertility medications are scaled back through the IVF/M process, the patient’s cost is reduced.Read more: How In Vitro Maturation (IVF/M) Helps to Increase IVF Pregnancy Success Rates

How AMH Plays a Key Role in Predicting a Woman’s Fertility

42592719 - happy pregnancy sitting on sofa at home in bedroomMeasuring a woman’s AMH level – Anti-Mullerian Hormone – is crucial to achieving a successful pregnancy through a fresh IVF transfer, as well as for an optimal egg freezing cycle. Why does this matter? AMH testing measure a woman’s ovarian reserve. A woman’s ovarian reserve determines the chances for conceiving and giving birth to a healthy baby using her own eggs. That’s not all. A recent study has found that fertile women having a low AMH level became pregnant less frequently than those with a higher AMH level.

A Woman’s AMH Level Decreases With Age

As a woman ages – post-35 – the count of her egg follicle (ovarian) reserve decreases. Did you know? Obese women have low AMH levels and poor ovarian reserves.

Bottom Line: As shown in the chart below, older women have lower AMH levels than their younger counterparts.

Age                             10th Percentile                     50th Percentile

18 – 24                       1.10                                        3.60

25 – 29                       1.10                                        3.20

30 – 34                       .52                                           2.10

35 – 39                       .20                                           1.50

40 – 41                       .10                                             .80

42 +                            .09                                             .50

Because women with lower AMH levels have less of an ovarian reserve than women with high AMH levels, AMH testing is key to predicting how a woman will respond to fertility medications. Here’s the deal: AMH testing helps Dr. Zhang predict your fertility level – that is – your chances of a successful pregnancy.

Women having low AMH levels do not respond well to fertility medications. These women are classified as poor responders because their bodies to not produce a sufficient number of high quality eggs using fertility medications.Read more: How AMH Plays a Key Role in Predicting a Woman’s Fertility

How to Reduce Your IVF Financial Risk: IVF SURE™

Healthy BabyIVF SURE™ is an outcome-based pricing service that helps to reduce our patients’ financial risk. Here’s the deal. Because IVF SURE™ guarantees results, you will get pregnant or we will refund your money. Our outcome-based IVF treatment pricing minimizes your IVF financial risk. Bottom Line: There are no hidden fees or costs to IVF treatment when using the IVF Sure™ guarantee program.

How IVF SURE™ Works For You

You pay a fixed fee – $25,000 – for three (3) fresh IVF cycles to be completed within a nine (9) month period. If you do not get pregnant – this fixed fee will be refunded. Fertility medication costs are not included in our IVF SURE™ program. This is an outcome-based fee schedule. The goal is to help you achieve a successful clinical pregnancy.

  • No Day 3 FSH/Estradiol testing required
  • No Anti-Mullerian Hormone (AMH) testing required
  • No disqualification because of previous failed IVF cycles

What’s the best part?

Most patients get pregnant within one or two cycles – 3 to 6 months – however, you have 9 months to participate in our IVF SURE™ program to receive a full fee refund. Time is not delayed during the 9 month period. Look: After a first failed IVF cycle – you can immediately begin the 2nd cycle.

Candidates for IVF SURE™

  • Women who are 38 years old or younger
  • Women who have regular menstrual cycles
  • Women who do not have regular periods because they are suffering from Polycystic Ovary Syndrome (PCOS)
  • Women who have qualifying male partners – IVF SURE™ does not cover TESA procedures (surgically retrieved sperm)

Read more: How to Reduce Your IVF Financial Risk: IVF SURE™

How to Get Pregnant Without Fertility Medications: Natural Cycle IVF™

Ethnic Couple (4)The Natural Cycle IVF™ protocol offered by New Hope Fertility Center in NYC focuses on producing one high quality egg without the use of fertility medications. Why is this important? Healthy, high quality eggs achieve superior IVF success rates for even those difficult patients who have been turned away from treatment at other fertility clinics. Bottom Line: When excessive eggs are produced using high dosages of fertility medications, many are not suitable for fertilization in vitro. Natural Cycle IVF™ is very user-friendly on patients – physically and financially.

Natural Cycle IVF™

Customized IVF care is the best. Remember: It only takes one good egg and one healthy sperm to make a baby. Our focus is to help you produce your one good egg during a fresh IVF cycle – not a high quantity of eggs using large doses of fertility medications.

Difficult Patients Welcome

Women diagnosed as difficult or hopelessly infertile by other fertility clinics are welcomed at New Hope Fertility Center. The best part? Because of our One Good Egg Policy, our fertility specialists happily accept candidates for IVF that other fertility clinics decline to treat because of advanced maternal age or other difficult medical conditions. Our One Good Egg Policy helps a woman produce her natural monthly egg for fertilization in vitro and transfer of a healthy embryo to her uterus for hopeful implantation. We believe a woman’s naturally produced egg can be the best quality and likeliest to result in a successful pregnancy.

If you have been deemed a poor responder to IVF treatment and told you could never conceive, come to New Hope Fertility Center for another opinion. We have successfully treated many women who have been told by other that they can never conceive.

Candidates for Natural Cycle IVF™

You may be a prime candidate for Natural Cycle IVF™ because:

  • You have a high follicle-stimulating hormone (FSH) level
  • You are at a high risk for developing Ovarian Hyperstimulation Syndrome (OHSS)
  • You are unable to produce 10 to 15 eggs during a single IVF cycle
  • You do respond to or cannot tolerate fertility medications
  • You are at an advanced maternal age for fertility treatment (over 35)
  • You are able to ovulate, but do not want to use fertility medication
  • You do not want to incur the cost of fertility medication
  • You do not want to produce multiple embryos

One Good Egg Policy

We believe that a woman’s naturally produced egg gives her the best chances of a successful pregnancy. Bottom Line: It’s the quality of a woman’s egg – not the quantity of eggs she is able to produce.Read more: How to Get Pregnant Without Fertility Medications: Natural Cycle IVF™

How the Gentle MINI-IVF™ Can Help You Get Pregnant

Ethnic Couple (2)Our Mini-IVF™ is a gentle – yet successful – holistic protocol helping to achieve pregnancy success for those women who have been struggling to have a baby. Because lower dosages of fertility medications are prescribed, only 3 to 5 high quality eggs are produce. The best part? Your cost per Mini-IVF™ cycle is reduced because less fertility medications are prescribed. Bottom Line: Pregnancy success rates for Mini-IVF™ are comparable to Conventional IVF.

The Revolutionary Mini-IVF™

In addition to reducing your cost for fertility medications, a Mini-IVF™ protocol lessens your physical discomfort.

  • Less fertility medication to produce 3 to 5 quality eggs
  • Cycle monitoring through ultrasound imaging and blood tests
  • Surgical egg retrieval
  • Fertilization of egg and sperm in vitro via (ICSI)
  • Culture and monitoring of embryo(s) via EmbryoScope technology
  • Grading and selection of quality embryo(s) for fresh transfer and/or future (FET)
  • Single Embryo Transfer (SET)

Candidates for Mini-IVF™

Mini-IVF™ is the best treatment protocol for:

  • Women diagnosed with blocked or damaged Fallopian tubes
  • Women diagnosed with Polycystic Ovarian Syndrome (PCOS)
  • Women diagnosed as having a risk of developing Ovarian Hyperstimulation Syndrome (OHSS)
  • Women diagnosed with a low ovarian reserve
  • Women diagnosed with cancer and are about to undergo treatment

Mini-IVF™ has also become the preferred treatment protocol for those:

  • Having failed multiple Conventional IVF cycles
  • Suffering from male-factor infertility
  • Wanting to reduce their costs of treatment
  • Wanting to reduce their risk of multiple pregnancy
  • Not wanting to create excessive embryos due to religious reasons
  • Wanting to reduce their use of injectable medications because of an aversion to needles
  • Wanting to undergo another fresh IVF cycle immediately after a failed cycle

Read more: How the Gentle MINI-IVF™ Can Help You Get Pregnant

What You Need To Know About Egg Donation

45569541 - couple looking at their sleeping baby girl, close upEgg donors are changing lives all over the globe. As an egg donor, you will be making a selfless effort to help other women who are unable to produce their own eggs. The best part? By using your young, healthy eggs, another woman will be able to achieve a successful pregnancy through In Vitro Fertilization (IVF). Bottom line: Because of your gift of life, your eggs will help other women carry a pregnancy to full term and become new mothers.

Profile of an Egg Donor

Young women who become egg donors must meet the following qualifications:

  • Be between the age of 18 and 28
  • Be in excellent health – nonsmoker with a normal body weight
  • Be free from any known familial, genetic, or sexually transmitted diseases
  • Pass all psychological, medical, and genetic testing required by the egg donor program

Egg Donor Program

Our egg donor coordinators work closely with you, recipients, and IVF medical staff throughout the entire donation process.

  • High compensation
  • Smooth application process
  • Confidential donation program
  • Easy to understand IVF process

ABC’s of Egg Donation

Your egg donation cycle will be ABC easy. Here’s the deal: A typical egg donation cycle can be completed within one to two months – from application to egg retrieval.

  • A – Apply by completing our prescreening application. This will help us determine if you are a potential candidate.
  • B – Be screened by our egg donor coordinator who will call you to schedule your first visit with us. At your office visit, you will undergo blood testing and a consultation with our egg donor coordinator.
  • C – Complete the egg retrieval process by undergoing a fresh IVF cycle. You will undergo a regimen of prescribed hormone injections that stimulate the ovaries into producing multiple egg follicles. Once mature, these egg follicles will be surgically retrieved by the doctor in an outpatient procedure.

Read more: What You Need To Know About Egg Donation

How Fertility Yoga Can Help Get You Pregnant

27878469 - lifestyle  cute, attractive woman during yoga exerciseWhen you are investing significant amounts of time, money, and emotion into an IVF cycle, you want to do everything you can to make it successful. Look: New studies have shown that both online yoga and in-person yoga help to increase the chances of a successful IVF pregnancy by up to 26 percent. This is because yoga is proven to reduce stress and anxiety in IVF patients.

Here’s the fertility yoga deal.

Yoga regimens include a series of poses and postures designed to improve fertility by:

  • Increasing blood flow to your reproductive system
  • Releasing stress
  • Reducing anxiety
  • Balancing life energy flow throughout the body
  • Helping to reset your endocrine system – aiding hormonal balance
  • Supporting a healthy immune system
  • Detoxifying the body
  • Creating clarity in your mind

Six weeks of in-person or online fertility yoga can reduce an IVF patient’s stress and anxiety between 23 and 26 percent. Now, you can experience the benefits of yoga by practicing online at home.

Benefits of Fertility Yoga

A thoughtful regimen of yoga during an IVF cycle combines mindful meditation with physical movement. Yoga is a great physical activity for preparing the body for undergoing the physical and emotional challenges of an IVF cycle.

That’s not all. Yoga prepares a woman’s body for pregnancy.

Physical activity through yoga in conjunction with IVF will:

  • Elicit a relaxation response in your body to reduce chronic stress
  • Counteract harmful stress hormones
  • Direct blood flow

There are many creative yoga sequences specifically designed to:

  • Center attention on breathing
  • Center attention on relaxing the mind and body

Read more: How Fertility Yoga Can Help Get You Pregnant

How to Plan Your Family Through Gender Selection

Pick of the MonthMany women undergoing IVF are choosing the sex of their baby through PGS/NGS technology. Celebrities and public figures, like Chrissy Teigen recently interviewed by Vogue, are increasingly opening up the discussion surrounding gender selection. Look: No longer is gender selection frowned upon as a social engineering tool used to make designer babies. What’s the bottom line? Gender selection is an accepted fertility procedure used to choose the sex of a baby for family balancing purposes.

Gender Selection Technology

Demand for gender selection is growing and our innovative IVF and genetic testing technology has been responding in kind with more than 99% accuracy. That’s not all. Gender selection is an inevitable by-product of genetic testing. Through genetic testing, the sex of each embryo is identifiable.

Preimplantation Genetic Screening (PGS) and Next Generation Sequencing (NGS)

PGS and NGS technology works to identify embryos with chromosomal abnormalities while they culture during the IVF process. The best part? PGS/NGS is the testing of an embryo’s overall chromosomal normalcy prior to being transferred to the patient’s uterus. Chromosomal abnormalities make an embryo too week to thrive into a fetus if it manages to implant into a woman’s uterine lining.

An Embryo’s Gender Chromosomal Make Up

The gender of an embryo is determined by the chromosomes carried in the sperm.

  • A man’s sperm can carry either the X or Y chromosome
  • A woman’s egg only contributes the X chromosome to the fertilized embryo
  • An embryo with XY makeup is male
  • An embryo with XX makeup is female

PGS Increases Pregnancy Rates By Up To 30 Percent

Universal blastocyst embryo screening is recommended for our patients because the procedure can help increase the chances of a pregnancy by 30 percent. Our fertility specialists recommend PGS/NGS in conjunction with IVF for:

  • Women over 37 who are undergoing IVF
  • Women who have had two or more unsuccessful IVF cycles
  • Women under 35 who have experienced two or more miscarriages – recurrent miscarriage
  • Women who are over 35 and have experience one miscarriage

Read more: How to Plan Your Family Through Gender Selection

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