How PGD is Helping to Eliminate Common Genetic Disease

52853590 - egg is holding by a pipet and a neeldle.When my patients are known carriers of a genetic disease – a single gene disorder – I strongly recommend Preimplantation Genetic Diagnosis (PGD) testing in conjunction with In Vitro Fertilization (IVF). Genetic diseases can be detected through PGD testing of embryos in vitro to eliminate passing on a single gene disorder to a child conceived via IVF.

Eliminate Common Genetic Disease From Being Passed On To Your Child

The most common genetic diseases tested for through PGD in conjunction with IVF are:

  • Hemophilia
  • Cystic Fibrosis
  • Sickle Cell Anemia
  • Tay Saches Disease
  • Spinal Muscular Atrophy
  • Duchennes Muscular Dystophy
  • Thalassemia

After a woman’s eggs have been surgically retrieved and fertilized in vitro, developing embryos will be tested upon reaching the blastocyst stage (5 to 6 days after fertilization occurs). Cells are gently removed from each embryo using microsurgery technology. Our expert embryologists then analyze the cells using a probe that is specifically designed to test for a specific gene disorder. PGD diagnoses a genetic defect in an embryo.

Only Healthy Embryos Are Transferred

Embryos testing positive for a genetic disease are not transferred to the woman’s uterus. Only healthy embryos are transferred.

PGD is conducted in conjunction with:

The Revolutionary Mini-IVF™

In addition to reducing your cost for fertility medications, a Mini-IVF™ protocol lessens your physical discomfort.

  • Less fertility medication to produce 3 to 5 quality eggs
  • Cycle monitoring through ultrasound imaging and blood tests
  • Surgical egg retrieval
  • Fertilization of egg and sperm in vitro via ICSI
  • Culture and monitoring of embryo(s) via EmbryoScope technology
  • Grading and selection of quality embryo(s) for fresh transfer and/or future (FET)
  • Single Embryo Transfer (SET)

Natural Cycle IVF™ and My One Good Egg Policy

My One Good Egg Policy helps a woman produce her natural monthly egg for fertilization in vitro and transfer of a healthy embryo to her uterus for hopeful implantation. I believe a woman’s naturally produced egg can be the best quality and likeliest to result in a successful pregnancy.

Natural Cycle IVF™ Process

  • As a woman’s natural cycle begins, the growth of her one good egg is monitored through ultrasound imaging and blood tests.
  • Once her natural egg has reached a prime stage of development, an ovulation trigger medication – hCG – will be self-administered by the patient at a designated time
  • On a scheduled date, the egg will be surgically retrieved in an outpatient procedure while the patient is under general anesthesia
  • After surgical retrieval, the egg will be fertilized in vitro through an ICSI procedure
  • ICSI is an ancillary IVF procedure in which one quality sperm is directly injected into the woman’s natural egg
  • Once a high quality embryo has cultured in vitro to a prime stage of development – it will then be transferred to the woman’s uterus via a thin catheter – similar to a Pap smear procedure
  • A pregnancy test is scheduled in approximately two weeks

Candidates for PGD

  • Women over 35 undergoing IVF using their own eggs
  • Couples having a history of multiple failed IVF attempts
  • Patients having a family history of genetic disease
  • Couples where one or both partners are known carriers of genetic disease
  • Couple who have a child born with a genetic disease
  • Couples who have a history of recurrent miscarriage

IVF Doctor Specializing in PGD to Eliminate Common Genetic Disease

To discover if PGD in conjunction with IVF can help you have a healthy baby free of genetic disease, contact Dr. John Zhang by calling 917.525.5496.

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