Category Archives: IVM

How In Vitro Maturation (IVM) Increases IVF Success Rates

40767153 - human ivfIVM or IVF/M – egg maturation in vitro – is a revolutionary method of Assisted Reproductive Technology (ART) helping to increase a woman’s chances of using at least some of her immature eggs for fertilization. The best part? IVM is an innovative ART technique that surgically retrieves a woman’s eggs while they are still in an immature stage. Look: A woman’s eggs can be matured in a controlled laboratory setting – in vitro – through IVF/M.

IVF/M Overview

After the woman’s immature eggs are surgically retrieved, they are placed in a petri dish containing a maturation medium for 24 to 48 hours in New Hope Fertility NYC’s state-of-the-art IVF lab. That’s not all. The retrieved eggs are carefully monitored as they fully mature outside of the woman’s body. Then, each individual egg is injected with a single sperm in a fertilization technique known as Intracytoplasmic Sperm Injection (ICSI). The resulting embryos are cultured for several more days until they have developed into a viable stage for transfer. Why does this matter? Only the highest quality embryos are selected for fresh IVF transfer or cryopreservation.

IVF/M Candidates

The best candidates for IVF/M:

  • Women diagnosed with Polycystic Ovarian Syndrome (PCOS)
  • Women at risk for Ovarian Hyperstimulation Syndrome (OHSS)
  • Cancer patients who may be sensitive to hormone therapy
  • Young women able to produce high numbers of egg follicles (10 to 15+) through fertility drug stimulation
  • Young women who have an acceptable AMH level
  • Women under 35 having an antral follicle count of 10 or more
  • Women who are at a healthy BMI – not obese

Read more: How In Vitro Maturation (IVM) Increases IVF Success Rates

What is Ovarian Tissue Freezing?

Fertility preservation is growing in popularity for a number of reasons.  Women of today are waiting longer to start a family.  Some women aim to achieve their personal goals before starting a family.  Other women are looking to become established professionally and then have children.  Another group of women may need to preserve their fertility for a medical reason.  Advancements in fertility medicine have allowed for a new method of fertility preservation – ovarian tissue freezing.EggFreezingImage_low_res

Ovarian Tissue Freezing Explained

A woman’s eggs are located in the outer layer of her ovaries.  During ovarian tissue freezing, the outer layer is removed from the body.  This layer contains a large number of eggs that have not yet matured.  Once retrieved, the layer is divided into strips and is frozen to be used later.  When a woman is ready to have children, the retrieved tissue is placed back into the body and is able to function normally.  This allows a woman who otherwise may have difficulty becoming pregnant with her own eggs to start a family.

Benefits of Ovarian Tissue Freezing

With traditional fertility preservation methods, such as egg and embryo freezing, mature eggs are retrieved after a cycle that uses fertility medication.  There is a limited number of eggs that can be achieved via this method, with an average of 10 mature eggs being retrieved during a single cycle.  When ovarian tissue freezing is done, hundreds of eggs can be retrieved and frozen at one time.  There is no need for fertility medication and no need to wait while the cycle progresses.

Further Advancements in Treatment

The field of fertility medicine is continually improving.  Great strides are being made in the specialty of in vitro maturation.  This process would allow eggs to be matured in a laboratory setting.  When this technology becomes widely used and understood, it would avoid the need to transfer the ovarian tissue back.  Instead, the IVF process could begin as soon as a woman is ready.

For additional information on ovarian tissue freezing or to learn about your options for fertility preservation, please contact a member of the New Hope Fertility Center team today.  Please click the link below to enter your information and New Hope will contact you, or simply call 212-517-7676.  Thank you.


Dr. John Zhang Discusses In-Vitro Maturization

Today I would like to discuss In-Vitro Maturization.


In-Vitro Maturization (IVM) is a technique that allows an egg that was not fully developed at the time of egg retrieval, to continue to mature in the lab. An immature egg takes more time to fertilize, therefore a woman’s ovulation time is around 14 days to insure that the egg will be at the proper stage for insemination. A culture medium is used to mature the egg, which contains important amino acids. Occasionally the amino acids can be supplemented with follicular fluid from the donor eggs to enhance egg maturation in the lab.

Read more: Dr. John Zhang Discusses In-Vitro Maturization