Preventing Genetic Disease Through PGD – Preimplantation Genetic Diagnosis

Genetic screening of embryos – Preimplantation Genetic Diagnosis (PGD) – allows fertility specialists to test and identify those embryos having a genetic defect. PGD prevents hereditary diseases from being passed from parents to their children. Dr. John Zhang recommends PGD in conjunction with IVF for couples who are known carriers of a single gene disorder (genetic disease).


PGD Detects Single Cell Genetic Diseases

The most common single cell genetic diseases tested for through PGD are:

  • Hemophilia
  • Cystic Fibrosis
  • Sickel Cell Anemia
  • Tay Saches Disease
  • Spinal Muscular Atrophy
  • Duchennes Muscular Dystrophy
  • Thalassemia

PGD Procedure in Conjunction with IVF

PGD is conducted in conjunction with Conventional IVF when embryos have reached the blastocyst stage in vitro (5 to 6 days culture). Cells are carefully removed from each embryo using a microsurgery technique. The DNA from the cells are then analyzed to determine if the embryo should be diagnosed as having a genetic disease. Only healthy, quality embryos are then transferred to the mother’s uterus for implantation and a successful pregnancy.

PGD is used in conjunction with Conventional IVF to increase the chance of transferring only a genetically disease-free embryo resulting in the birth of a healthy baby.

Dr. Zhang also recommends PGD be conducted in conjunction with:

Other Benefits of PGD 

It is important to note that PGD does not detect HIV. When PGD is used in conjunction with the IVF procedure, the chance of losing a baby due to genetic disease, or having a child born with birth defects, is dramatically reduced.  While this process does not eliminate the need for testing during pregnancy, it provides a number of assurances. Through PGD, more invasive testing such as amniocentesis can be avoided during the pregnancy, further reducing the likelihood of a fluid exchange between an HIV mother and unborn baby. Avoiding fluid transmission is one way to increase the odds of having a baby born HIV negative.

PGD Specialist – Dr. John Zhang

To discover if PGD in conjunction with IVF can help you have a healthy baby free of genetic disease, contact fertility specialist Dr. John Zhang.

Schedule your initial consultation with Dr. John Zhang by calling 917-525-5496.


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